The Efect of Nano‑chitosan and Nano‑curcumin on Radiated Parotid Glands of Albino Rats: Comparative Study

Research Abstract

According to the histopathological examination, the gland in control group appeared to be composed of parenchyma and connective tissue stroma. In radiated group, serous acini lost its architecture and arrangement. The nuclei of serous acinar cells showed hyperchromatism, pleomorphism, abnormal mitotic figures, karyomegaly and perinuclear haloing. Intercalated ducts appeared dilated with entrapped secretion, its lining cells with abnormal nuclear morphology. Striated ducts appeared with stagnant secretion, cell proliferation and abnormal nuclear morphology. Excretory duct appeared with distorted morphology, rupturing in lining cell basement membrane, stagnant secretion and surrounded by hyalinized CT. Blood vessels appeared engorged with red blood cells. In curcumin and chitosan nanoparticles the parotid gland began to restore its normal histological structure.

Research Keywords

radiation-parotid gland