Basic Informations

C.V

graduated from cairo university 2010
master 2016
phd20234

Master Title

The Anti-aging Role of Curcumin and Fisetin on induced aged Parotid Glands of Albino Rats (an animal study)

Master Abstract

Summary Nature is full of good. Our role is to use it to withstand diseases ghost without any side effects. Xerostomia is one of these ghosts, which may be associated with a change in the composition of saliva, or reduced salivary flow (hyposalivation). Bossola et al., (12) reported that xerostomia is associated with old age. The free Radical/oxidative stress theory of aging is currently one of the most popular explanations for how aging occurs. Therefore, the present study was conducted to compare curcumin and fisetin (both are natural dietary derivatives which were reported as anti-oxidant substrates) in treating the histological and the structural changes in aged rats’ parotid glands. The current study was done on 30 adult male albino rats that received a daily 0.5 ml of 5% D-galactose injected subcutaneously for 30 days, then allocated in to 3 groups. • Group A (aging group): which received 5% D-galactose for another 30 days • Group C (curcumin group): which received 5% D-galactose and curcumin for another 30 days. • Group F (fisetin group): which administrated 5% D-galactose and fisetin for another 30 days.

PHD Title

THE EFFECT OF NANO-CHITOSAN AND NANO-CURCUMIN ON RADIATED PAROTID GLANDS OF ALBINO RATS (COMPARATIVE STUDY)

PHD Abstract

Summary Radiotherapy utilization rates for cancer vary widely internationally. It has previously been suggested that approximately 50% of all cancer patients should receive radiation (Delaney et al., 2005). Radiotherapy-induced damage in the oral mucosa is the result of the deleterious effects of radiation, not only on the oral mucosa itself but also on the adjacent salivary glands, bone, dentition, and masticatory musculature and apparatus. Radiotherapy-induced oral complications are complex, dynamic pathobiological processes that lower the quality of life and predispose patients to serious clinical disorders (Sciubba & Goldenberg, 2006). Aim: The present study was conducted to investigate curcumin and chitosan nanoparticles (both are natural dietary derivatives which were reported as anti-oxidant substrates) in treating the histological and the structural changes in radiated rats’ parotid glands. Material and methods: Animals Sixty adult male Albino rats with an average weight 200-250 g. They were kept in individual cages. All experiments were conducted in the animal house in National Center for Radiation Research and Technology, Egypt. Chemicals 1-Chitosn powder was procured from M/s Sigma Chemical Company. 2-Curcumin, turmeric curcumin powder pure from now food company. Summary 95 Experimental design The current study was done on 60 adult male albino rats that distributed in four groups • Group I (control group): which consisted of 15 healthy rats away from the radiation building. • Group II (radiated group): Consisted of 15 rats. Rats were arranged in cylinders so that the heads were exposed to radiation source (cobalt 60 source, energy 1.25 MV (millivolts)). • Group III (curcumin nano-particles treated group): Consisted of 15 rats, each received a daily nanocurcumin which was diluted by distilled water (1:8) (Modasiya & Patel, 2012) • Group IV (chitosan nano-particles treated group): Consisted of 15 rats, each was received Nano-chitosan (200 mg/kg body weight per day, MW 3?80?000 Da). Chitosan 0.3% was dissolved in 2% of acetic acid to form chitosan solution (Laudenslager et al., 2008